Immunomodulatory effects of ginsenoside Rg3 on tumors and its nano-drug delivery system
10.7501/j.issn.0253-2670.2019.15.032
- Author:
Man WANG
1
Author Information
1. Department of Traditional Chinese Medicine, Shanghai Changhai Hospital, Naval Military Medical University
- Publication Type:Journal Article
- Keywords:
Ginsenoside Rg3;
Immunology;
Nano-drug delivery system;
Tumor;
Tumor microenvironment
- From:
Chinese Traditional and Herbal Drugs
2019;50(15):3729-3734
- CountryChina
- Language:Chinese
-
Abstract:
Immune escape is an important mechanism for the development of tumors. Re-activating the anti-tumor immune response is a key measure for the treatment of malignant tumors. Ginsenoside Rg3 (G-Rg3) is a sterol compound isolated from Panax ginseng. It can improve the anti-tumor immune response of human by up-regulating the autoantigenicity and immunogenicity of tumor cells, enhancing the function of immune effector cells and immune active molecules, and regulating the local immune microenvironment. However, the clinical application of G-Rg3 is limited due to its poor water solubility and low bioavailability. Improved drug delivery systems are the key to solving this problem. Therefore, this paper summarizes the research progress of G-Rg3 on tumor immunoregulation and its nano-drug delivery systems, in order to provide reference for the in-depth study and clinical application of G-Rg3.
