Regulation of components of Shufeng Jiedu Capsule on immune system of pneumonia model rats
10.7501/j.issn.0253-2670.2019.15.007
- Author:
Li MA
1
Author Information
1. Tianjin Institute of Pharmaceutical Research Drug Safety Assessment Co., Ltd.
- Publication Type:Journal Article
- Keywords:
Bradykinin;
Complement;
Immune organ;
Immune system;
Immunoglobulin;
Lymphocyte;
Monocyte chemokine protein-1;
Shufeng Jiedu Capsule
- From:
Chinese Traditional and Herbal Drugs
2019;50(15):3563-3568
- CountryChina
- Language:Chinese
-
Abstract:
Objective: In this study, we disassembled the prescription of Shufeng Jiedu Capsule to research the effects of the heat-clearing and detoxifying component, the relieving exterior component and their compatibility on the serum immune system of rats with acute pneumonia respectively, so as to analyze the compatibility rationality of Shufeng Jiedu Capsule. Methods: Shufeng Jiedu Capsule was divided into two components to study the compatibility rationality, which were relieving exterior component and heat-clearing and detoxifying component. The pneumonia model rats induced by Streptococcus pneumoniae was used to observe the effects of Shufeng Jiedu Capsule and its ingredients on peripheral blood lymphocyte classification, serum immunoglobulin level, serum complement protein 3 (C3), vascular bradykinin (BK), monocyte chemoattractant protein 1 (MCP-1), weight of immune organ and lung of pneumonia rats. The relationship between the Shufeng Jiedu Capsule and its decomposing agent was analyzed by Kim’s formula. Results: The whole prescription, the relieving exterior component and the heat clearing and detoxifying component significantly reduced the proportion of B lymphocyte, and increased CD4+/CD8+. The whole prescription and the relieving exterior component significantly increased the proportion of NK cells and decreased the proportion of CD8+. The Q values of rats in the whole prescription group were more than 1 on two indicators, which were the proportion of B lymphocyte and proportion of NK cell. The whole prescription significantly reduced the content of IgM. The whole prescription and relieving exterior component significantly reduced the content of IgG. The content of BK and MCP-1 in the whole prescription and the heat-clearing and detoxifying component was significantly decreased, and the content of MCP-1 in relieving exterior component was significantly decreased. The weight of thymus, spleen, and lung was significantly reduced by the whole prescription and the relieving exterior component. The weight of lung was significantly reduced by the heat clearing and detoxifying component. Relieving exterior component and the heat clearing and detoxifying component had synergistic effect on the weight of the three organs. Conclusion: Shufeng Jiedu Capsule had significant therapeutic effect on Streptococcus pneumoniae infected rats, and significantly regulated immune function by reducing the levels of serum IgM, IgG, BK, and MCP-1. In this model, the relieving exterior component and the heat clearing and detoxifying component have significant synergistic effects, which are mainly reflected in the following indicators: B lymphocyte ratio, NK cell ratio, weight of thymus, spleen, and lung.
