Study on mechanism of anti-inflammation and immunoregulation of Shufeng Jiedu Capsule based on network pharmacology
10.7501/j.issn.0253-2670.2019.15.006
- VernacularTitle: 基于网络药理学的疏风解毒胶囊抗炎和免疫调节作用机制研究
- Author:
Yan-Qi HAN
1
Author Information
1. National & Local United Engineering Laboratory of Modern Preparation and Quality Control Technology of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research
- Publication Type:Journal Article
- Keywords:
Anti-inflammation;
Immunoregulation;
Mechanism;
Network pharmacology;
Shufeng Jiedu Capsule
- From:
Chinese Traditional and Herbal Drugs
2019;50(15):3555-3562
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the network regulation mechanism of anti-inflammation and immunoregulation of Shufeng Jiedu Capsule (SJC). Methods: Targets of the 28 compounds in SJC were predicted according to the reverse pharmacophore method. Gene ontology (GO) function enrichment and pathway analysis of the targets were analyzed by MAS 3.0 software and Kyoto Gene and Genome Encyclopedia (KEGG) database. Finally, Cytoscape software was used to construct the network pharmacology map. Results: A total of 28 compounds affected 112 pathways through 127 targets, of which 41 targets and 22 pathways were associated with anti-inflammation and immunoregulation. The network of compound-target-pathway-pathology process was also constructed. Conclusion: SJC interferes with multiple biological processes related to anti-inflammation and immunoregulation by acting on several key proteins such as HRAS, MAP2K1, AKT1, MME, and PTPN1. The mechanism of SJC was preliminarily revealed.
