Spectrum-effect relationship of wind-dispersing and exterior syndrome-relieving of Shufeng Jiedu Capsules
10.7501/j.issn.0253-2670.2019.15.003
- Author:
Yan-Qi HAN
1
Author Information
1. National & Local United Engineering Laboratory of Modern Preparation and Quality Control Technology of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research
- Publication Type:Journal Article
- Keywords:
Dihydrodylate glycoside;
Emodin;
Forsythoside E;
Neural network;
Phillyrin;
Polydatin;
Rhein;
Saikosaponin d;
Shufeng Jiedu Capsule;
Spectrum-effect relationship;
Verbascoside;
Wind-dispersing and exterior syndrome-relieving
- From:
Chinese Traditional and Herbal Drugs
2019;50(15):3534-3540
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the potential effective compounds of ‘wind-dispersing and exterior syndrome-relieving’ of Shufeng Jiedu Capsule (SJC). Methods: The fingerprints of 22 samples with different proportions of SJC were established by LC-MS. The stimulation rates of 22 samples to the M3 receptor were measured by Chinese hamster ovarian cancer cells with high expression of M3 acetylcholine receptor which related to ‘wind-dispersing and exterior syndrome-relieving’. Finally, the spectrum-effect relationship of relative peak areas of characteristic peaks and stimulation rates was analyzed by BP-neural network. Results: According to the established optimal neural network model, 16 characteristic peaks were calculated and found to be significantly correlated with the activity of SJC on the M3 receptor stimulation. Conclusion: Through the spectrum-effect study, it is speculated that the effective components of SJC on ‘wind-dispersing and exterior syndrome-relieving’ may be the 16 compounds including dihydrodylate glycoside, emodin, rhein, phillyrin, forsythoside E, saikosaponin d, polydatin, verbascoside, etc, which provides a basis for the determination of quality markers.
