Quality evaluation strategy of Chinese materia medica preparation based on characteristics of “structural composition of multi-components”
10.7501/j.issn.0253-2670.2019.17.002
- Author:
Bing YANG
1
Author Information
1. School of Traditional Chinese Pharmacy, China Pharmaceutical University
- Publication Type:Journal Article
- Keywords:
Chinese materia medica preparation;
Holistic view;
Quality evaluation;
Representative components;
Structural composition of multi-components
- From:
Chinese Traditional and Herbal Drugs
2019;50(17):4003-4007
- CountryChina
- Language:Chinese
-
Abstract:
The scientific and objective quality evaluation of traditional Chinese medicine preparations has always been a historical problem in the process of modernization of traditional Chinese medicine. In the past, the single component evaluation model of “point for surface, one for all” and the index selection method of “content-only theory” were mostly used in the quality evaluation of traditional Chinese medicine preparations, which seriously deviated from the characteristics of the overall view of traditional Chinese medicine, and it was difficult to objectively and accurately evaluate the quality of traditional Chinese medicine preparations. At present, the quality evaluation model of traditional Chinese medicine preparations based on multiple indicators has become the consensus of many experts and scholars. However, the complexity of the multi-components of traditional Chinese medicines has made it impossible to accurately identify all the components in the quality evaluation of traditional Chinese medicine preparations, and it is even more impossible to use all the components as the standard for quality evaluation. According to the characteristics of traditional Chinese medicine, a limited number of representative components which can represent the overall effect of traditional Chinese medicine preparations were selected by means of network pharmacology, molecular docking, etc. Based on the content of representative components and their proportional relationship, the quality evaluation strategy of traditional Chinese medicine preparation based on the characteristics of “components structure” was established, in order to provide new ideas for the quality evaluation of traditional Chinese medicine preparations in the future.
