Research progress on molecular mechanism of Chinese materia medica affecting bone metabolism
10.7501/j.issn.0253-2670.2019.20.036
- VernacularTitle: 中药影响骨代谢分子机制研究进展
- Author:
Yan ZHANG
1
Author Information
1. School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Bone metabolism;
Chinese materia medica;
NF-κB signal pathway;
OPG/RANKL/RANK signal pathway;
TGF-β/ BMP/Smad signal pathway;
Wnt/β-catenin signal pathway
- From:
Chinese Traditional and Herbal Drugs
2019;50(20):5096-5102
- CountryChina
- Language:Chinese
-
Abstract:
Dynamic balance of bone metabolism is one of the important factors to maintain normal osseous tissue function. When the balance is broken, it causes bone damage and even bone metabolic disease. However, the mechanism of bone metabolism is still unclear, the signal pathway is complex, and the treatment of diseases is still under study. The research on the mechanism of bone metabolism by Chinese materia medica has become a new direction in the treatment of bone metabolism diseases. At present, common mechanisms in bone metabolism include OPG/RANKL/RANK signal pathway, Wnt/β-catenin signal pathway, TGF-β/BMP/Smad signal pathway, and NF-κB signal pathway. In this paper, the research on the above pathways was reviewed, so as to provide a reference for further exploring the treatment of bone metabolism diseases with Chinese materia medica.
