One new 2-(2-phenylethyl) chromone derivative from agarwood of Aquilaria crassna in Cambodia
10.7501/j.issn.0253-2670.2019.20.003
- Author:
Lu-Lu XIA
1
Author Information
1. Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Bio-technology, Chinese Academy of Tropical Agricultural Sciences
- Publication Type:Journal Article
- Keywords:
6-methoxy-8-hydroxy-2-(2-phenylethyl) chromone;
Agarwood;
Aquilaria crassna Pierre ex Lecomte.;
Cambodia;
Cytotoxic activity
- From:
Chinese Traditional and Herbal Drugs
2019;50(20):4863-4866
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the chemical constituents of agarwood originating from Aquilaria crassna in Cambodia. Methods: The compounds were isolated and purified by silica gel column chromatography and semi-preparetive HPLC and so on. Their structures were identified by spectroscopic data. All compounds were tested for cytotoxic activities against two human cancer cell lines by MTT method. Results: Four compounds were isolated and elucidated as 6-methoxy-8-hydroxy-2-(2-phenylethyl) chromone (1), 6-methoxy-7-hydroxy-2-[2-(4-methoxyphenyl) ethyl] chromone (2), 7β,8β-epoxy-6α-hydroxy-5α-methoxy-5,6,7,8-tetrahydro-2-[2-(4- methoxyphenyl) ethyl] chromone (3), and rel-(1aR,2R,3R,7bS)-5,6-epoxy-7,8-dihydroxy-5,6,7,8-tetrahydro-2-[2-(4-methoxyphenyl) ethyl] chromone (4). Conclusion: Compound 1 is a new compound, while compounds 2-4 are isolated from this agarwood for the first time. Among them, compound 4 showed inhibitory activities against SGC-7901 and A549 cells.
