A new lactone from Alternaria sp. IS275, an endophytic fungus of Ligusticum chuanxiong
10.7501/j.issn.0253-2670.2019.20.002
- VernacularTitle: 川芎内生真菌次级代谢产物中1个新的内酯化合物
- Author:
Xin-Rui LI
1
Author Information
1. State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, College of Pharmacy, Chengdu University of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Endophytic fungi;
Ligualterlide A;
Ligusticum chuanxiong Hort.;
New lactone compound;
Secondary metabolites
- From:
Chinese Traditional and Herbal Drugs
2019;50(20):4859-4862
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the chemical constituents of metabolites of Alternaria sp. IS275, an endophytic fungus isolated from Ligusticum chuanxiong. Methods: The extraction fraction of ethyl acetate from endophytic fungi fermentation broth of L. chuanxiong were isolated and purified by silica gel, Sephadex LH-20, reversed phase medium pressure chromatography, preparative TLC, and semi-preparative RP-HPLC. The structure of the separated chemical constituent was elucidated by modern spectroscopy technology. Results: A new lactone compound (+)-4,11-dihydroxy-2-dodecene-5-lactone was isolated from the ethyl acetate fraction of the metabolite of Alternaria sp. IS275, an endophytic fungus of L. chuanxiong. Conclusion: Compound 1 is a new lactone compound, named ligualterlide A.
