Sesquiterpenes and steroids from Subergorgia suberosa
10.7501/j.issn.0253-2670.2019.23.007
- Author:
Xian-Qiang CHEN
1
Author Information
1. Institute of Marine Drugs, Guangxi University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Cholesterol;
Ergosterol;
Pregnane;
Sebergorgia suberosa (Pallas);
Sesquiterpenes;
Steroids;
Subergane-type sesquiterpene;
Suberosane-type sesquiterpene
- From:
Chinese Traditional and Herbal Drugs
2019;50(23):5683-5689
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the chemical constitutes of Subergorgia suberosa from South China Sea. Methods: We carried out the chemical separation of EtOH extract of S. suberosa based on the chromatographic techniques such as medium pressure preparative chromatography, silica, sephadex LH-20, ODS column chromatography, and preparative thin layer chromatography (PTLC). The NMR and MS spectroscopic techniques, together with comparison with literature data, were used for structural elucidation of compounds. Results: Fourteen compounds including sesquiterpenes and steroids were isolated from S. suberosa. These compounds were identified as subergorgic acid methyl ester (1), 2β-hydroxy subergorgic acid methyl ester (2), subergorgic acid (3), suberosenol A (4), suberosenol B (5), suberosenone (6), suberosanone (7), 3β-hydroxy-5β-pregnan-20-one (8), 3β-hydroxy-5α-pregnan-20-one (9), 3α-hydroxy-5β-pregnan-20-one (10), pregnan-4-ene-3,20-dione (11), 3β-hydroxy-pregnan-5-ene-20-one (12), cholesterol (13), and 5α,8α-epidioxyergosta-6,22-dien-3β-ol (14), respectively. Conclusion: Compounds 5 and 10 are isolated from the family Subergorgiidae for the first time. Compound 14 is isolated from S. suberosa for the first time.
