Study on chemical constituents from whole herbs of Sargassum fusiforme
10.7501/j.issn.0253-2670.2019.23.005
- Author:
Si-Yu WANG
1
Author Information
1. College of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Dihydroquercetin;
Lupenone;
Sargassum fusiforme (Harv.) Setch.;
Secondary metabolites;
Sesquiterpenes;
Sterols;
Triterpenoids;
Β-amyrenone
- From:
Chinese Traditional and Herbal Drugs
2019;50(23):5670-5676
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the chemical constituents of the whole herbs of Sargassum fusiforme. Methods: The chemical constituents from S. fusiforme were separated and purified by silica gel, MCI, ODS, Sephadex LH-20 gel column chromatographies, and preparative HPLC. Their structures were identified by analysis of NMR, MS, ORD, etc, and comparing physicochemical properties of compounds with references. Results: A total of 19 compounds were obtained from the 50% ethanol-H2O extract of S. fusiforme, and their structures were determined as lupenone (1), bauerenone (2), β-amyrenone (3), α-amyrenone (4), loliolide (5), isololiolide (6), (3S,5R,6S,7E)-5,6-epoxy-3-hydroxy-7-megastigmen-9-one (7), (R)-dehydrovomifoliol (8), 24-ethylcholesta-4,24 (28)-dien-3-one (9), fucosterol (10), 29-hydroperoxystigmasta-5,24 (28)-dien-3β-ol (11), 24-hydroperoxy-24-vinylcholesterol (12), saringosterol (13), (24R)-5,28-stigmastadiene-3β,24-diol-7-one (14), dihydroquercetin (15), aurantiamide acetate (16), dibutyl phthalate (17), glycerol monopalmitate (18), and methyl hexadecanoate (19). Conclusion: The compounds isolated from S. fusiforme were mainly identified as triterpenoids, sesquiterpenoids, highly oxidized sterols, alkaloids and so on. Compounds 1-4, 7-8 and 14-19 are isolated from S. fusiforme for the first time.
