Efficient discovery and medicinal research of marine natural products
10.7501/j.issn.0253-2670.2019.23.001
- Author:
Wei-Ming ZHU
1
Author Information
1. Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China
- Publication Type:Journal Article
- Keywords:
Chemodiversity;
Druggability;
Marine drugs;
Marine microorganisms;
Marine natural products
- From:
Chinese Traditional and Herbal Drugs
2019;50(23):5645-5652
- CountryChina
- Language:Chinese
-
Abstract:
Marine natural products (MNPs) are the source of modern marine drugs, but they have the characteristics of strong guiding function and weak druggability. How to quickly and efficiently discover new bioactive MNPs and optimize their druggability is an important idea for the research and development of innovative marine drugs. This article has made some discussions and suggestions on this emphasis from the origin and characteristics of MNPs, marine microorganisms with specific productivity for MNPs and the strategies of microbial MNPs with high yields and diverse structures, as well as the structural modification for medicinal use of MNPs.
