Feasibility of stem cell therapy for renal ischemia/reperfusion injury: A systematic review based on animal experiments
10.3969/j.issn.2095-4344.2078
- Author:
Zhi Zhong SHANG
1
Author Information
1. Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University
- Publication Type:Journal Article
- Keywords:
Animal experiment;
Clinical transformation;
Efficacy;
Ischemia/reperfusion injury;
Kidney;
Stem cells;
Systematic review;
Universal cells
- From:
Chinese Journal of Tissue Engineering Research
2020;24(25):4094-4100
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: With the in-depth investigation of stem cells and better understanding of kidney ischemia/reperfusion injury, stem cell therapy for renal ischemia/reperfusion injury in animal experiments have been developed extensively, and have achieved certain advance. Therefore, it is necessary to conduct a systematic evaluation to explore the specific efficacy of stem cell therapy for renal ischemia/reperfusion injury. OBJECTIVE: To systematically evaluate the effects of stem cells on the function and structure of the kidney and the immune function of the body and the feasibility of transformation into clinical practice based on the animal experiments. METHODS: Databases of PubMed, Web of Science, Embase, CNKI, VIP and WanFang were searched by computer, and the search time was limited before May 2019. The literature was screened independently by two researchers, and the data were extracted. SYRCLE animal experiment bias risk assessment tool was used to evaluate the methodological quality of the study, and the evidence quality was evaluated using CERQual tool.
