Difference of CTC detection in the prognosis of gastric cancer and colorectal cancer
- Author:
Lin ZHAO
1
Author Information
- Publication Type:Journal Article
- Keywords: Circulating tumor cell; Colorectal cancer; Gastric cancer; ImFISH technique; Negative enrichment technique
- From: Journal of Xi'an Jiaotong University(Medical Sciences) 2019;40(6):942-946
- CountryChina
- Language:Chinese
- Abstract: Objective: To investigate the clinical significance and difference of peripheral blood circulating tumor cells (CTCs) detection in the prognosis of patients with gastric cancer and colorectal cancer. Methods: The CTCs in the peripheral blood of 32 patients with gastric cancer and 36 patients with colorectal cancer were detected by negative enrichment and imFISH technique, and the results were compared between the two groups. Results: There were 8 cases (25%) of CTCs < 2 in the peripheral blood of gastric cancer patients. At the end of the follow-up, all patients survived; 24 cases (75%) of CTCs >2 were detected, and only 8 cases survived. The two groups differed significantly in survival (P=0.001). 28 cases (78%) of the patients with colorectal cancer were detected CTCs < 2 groups in the peripheral blood. At the end of the follow-up, all patients survived. 8 cases (22%) of the patients with CTCs > 2 groups survived at the end of the follow-up. 6 patients survived at the end of the follow-up. There was a significant difference between CTCs < 2 groups and CTCs > 2 groups in colorectal cancer (P=0.044). The survival in gastric cancer and colorectal cancer was significantly different (P=0.000). The results of CTCs were not correlated with gender, age, lymph node metastasis, distant organ metastasis or pathological grade of patients with colorectal cancer and gastric cancer (all P>0.05). Conclusion: Negative enrichment and imFISH technique can be used to detect CTCs of the peripheral blood of patients with gastric cancer and colorectal cancer. The prognosis of patients with elevated CTCs is poor. Gastric cancer has a poorer prognosis than colorectal cancer.
