Association between carotid atherosclerosis and ischemic stroke in the population with a high risk for stroke
- Author:
Hai-Lei YANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Carotid atherosclerosis; Community cohort study; Ischemic stroke; Risk factor
- From: Journal of Xi'an Jiaotong University(Medical Sciences) 2019;40(6):916-921
- CountryChina
- Language:Chinese
- Abstract: Objective: To investigate the relationship between carotid atherosclerosis and ischemic stroke in the population with a high risk for stroke from Yanta District, Xi'an. Methods: The subjects were selected from Screening and Prevention Program of Stroke in Yanta District, Xi'an, in 2012. All of them received carotid ultrasound examination and were followed up by telephone 4 years later. Chi-square test, analysis of variance, and multivariate cox regression model analysis were performed to investigate the correlation between carotid atherosclerosis and ischemic stroke. Results: A total of 774 subjects met the inclusion criteria, and 4 years later 39 lost to follow-up, 17 refused to be investigated, 4 patients underwent carotid artery stenting, and 4 patients had cerebral hemorrhage, Finally, 710 patients were included in the analysis, and the age was 45-98 years (59.75 years ±9.58 years) with males being 282 (39.7%). During the follow-up, 50 participants were diagnosed as having ischemic stroke. The incidence of ischemic stroke in the carotid atherosclerosis group was higher than that in the non-atherosclerosis group (13.1% vs. 5.2%, P<0.001). K-M survival analysis showed that the survival time in the non-carotid atherosclerosis group was longer than that in the carotid atherosclerosis group. Multivariable Cox regression analysis showed that age, history of stroke, family history of coronary heart disease or diabetes, medication on hypoglycemics and lipid-lowering drugs, abnormal level of high-density lipoprotein and carotid atherosclerosis were significantly associated with ischemic stroke. It also showed that carotid atherosclerosis was an independent factor for ischemic stroke (HR=2.529, 95% CI: 1.150-5.563, P=0.029). Conclusion: Carotid atherosclerosis in the population with a high risk for stroke significantly increases the risk of ischemic stroke.
