Correlation between the level of serum uric acid and renal functions in type 2 diabetic patients
- Author:
Minmin LI
1
Author Information
- Publication Type:Journal Article
- Keywords: Chronic kidney disease; Hyperuricemia; Type 2 diabetes
- From: Journal of Xi'an Jiaotong University(Medical Sciences) 2020;41(2):230-234
- CountryChina
- Language:Chinese
- Abstract: Objective: To investigate the prevalence of hyperuricemia in type 2 diabetic patients and explore the correlation between the level of serum uric acid and kidney functions in type 2 diabetic patients. Methods: The demographic and clinical data of type 2 diabetic patients treated in The First Affiliated Hospital of Xi'an Jiaotong University from January 2018 to December 2018 were collected and retrospectively analyzed. Measurement data were described by mean±SD, and enumeration data were presented by percentage. Pearson correlation and Logistic regression were performed to evaluate the correlation between the level of serum uric acid and kidney functions. Results: Of all the 808 type 2 diabetic patients aged 54.81±14.26 years, 525 (64.98%) were males and 283 (35.02%) were females. The prevalence of hyperuricemia in type 2 diabetic patients was 16.46%. Pearson correlation analysis showed that the level of serum uric acid was negatively associated with estimated glomerular filtration rate (eGFR) (r=-0.181, P<0.001). Multivariate Logistic regression analysis showed that compared with the level of serum uric acid in the first quartile group (<253 μmol/L), the multivariate-adjusted odds ratio of chronic kidney disease (CKD) in the second (253-309 μmol/L), third (309-368 μmol/L) and fourth (>368 μmol/L) quartile group was 1.55 (95% CI: 0.71-3.37), 4.03 (95% CI: 1.89-8.49) and 7.09 (95% CI: 3.37-14.89), respectively. Conclusion: The level of serum uric acid is negatively associated with eGFR. High level of serum uric acid is associated with increased prevalence of CKD.
