Interhemispheric functional connectivity in patients with end-stage renal disease: A resting-state functional MRI study
- Author:
Qiao GUO
1
Author Information
- Publication Type:Journal Article
- Keywords: Cognitive impairment; End-stage renal disease; Magnetic resonance imaging; Neural network
- From: Journal of Xi'an Jiaotong University(Medical Sciences) 2020;41(2):177-181
- CountryChina
- Language:Chinese
- Abstract: Objective: To investigate the alterations of functional connectivity between inter-hemisphere of patients with the end-stage renal disease (ESRD) and its relationships with cognitive impair mentusing oxel-mirrored homotopic connectivity (VMHC) based on resting-state fMRI (rs-fMRI). Methods :Totally 27 patients with ESRD (ESRD group) and 26 normal volunteers (control group) were enrolled and underwent rs-fMRI scanning. Montreal Cognitive Assessment (MoCA, Chinese version) was performed on each participant to evaluate the cognitive function. VMHC value between brain hemispheres was calculated with DPABI software based on rs-fMRI data, and the regions with statistically different VMHC value were obtained. The correlation between VMHC in the regions with statistical differences and MoCA scores was evaluated. Results: Compared with control group, significantly lower VMHC value was found in precentral gyrus, rolandic operculum, postcentral gyrus, inferior parietal lobule, superior temporal gyrus, amygdala, parahippocampa gyrus, fusiform gyrus and insula in ESRD group (GRF correction; voxel level P<0.001, cluster level, P<0.05). VMHC value of inferior parietal lobule correlated positively with MoCA scores (r=0.419, P<0.05). Conclusion: Significant abnormal inter-hemisphere functional connectivity is found in patients with ESRD. Among them, inferior parietal lobule may play an important role in the process of cognitive impairment.
