Value of hypoxia-inducible factor 1α in diagnosis and prognosis of acute decompensated chronic heart failure
10.3969/j.issn.1674-8115.2018.04.013
- Author:
Ke-Yuan SUN
1
Author Information
1. Department of Geriatrics, Sixth People's Hospital, Shanghai Jiao Tong University
- Publication Type:Journal Article
- Keywords:
Acute decompensated chronic heart failure;
Diagnosis;
Hypoxia-inducible factor 1α;
Prognosis;
Type B natriuretic peptide
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2018;38(4):426-429
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the value of hypoxia-inducible factor 1α (HIF-1α) in diagnosis and prognosis of acute decompensated chronic heart failure (CHF). Methods: 32 patients with acute decompensated CHF (Group A), 33 patients with stable CHF (Group B) and 30 controls (Group C) were included. HIF-1α, B-type natriuretic peptide (BNP) and other biochemical indicators in blood were detected. Length of stay and readmission frequency within 3 months of Group A were recorded. Correlations between HIF-1α and other indicators were analyzed. ROC curves of HIF-1α and BNP were developed to compare their diagnostic values. Results: The HIF-1α and BNP levels of Group A were both significantly higher than those of Group B and Group C (P<0.05). HIF-1α was positively correlated with serum creatinine, hemoglobin, BNP, length of stay and readmission frequency within 3 months (P<0.05). Areas under curves of HIF-1α and BNP showed no statistically difference (P>0.05). Conclusion: HIF-1α has a certain value in diagnosis and prognosis of acute decompensated CHF.
