Mechanism of Wdpcp in regulating coronary artery development
10.3969/j.issn.1674-8115.2018.04.001
- Author:
Xiang-Yang LIU
1
Author Information
1. Shanghai Pediatric Congenital Heart Disease Institute, Pediatric Translational Medicine Institute, Shanghai Jiao Tong University
- Publication Type:Journal Article
- Keywords:
Coronary artery development;
Epicardial derived cell;
Epithelial-mesenchymal transition;
Wdpcp gene
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2018;38(4):361-363
- CountryChina
- Language:Chinese
-
Abstract:
Wdpcp, a planar cell polarity (PCP) effector gene, plays essential roles in organogenesis during embryonic development through regulating collective cell movement and ciliogenesis. WDPCP mutations are associated with Bardet-Biedl syndrome and Meckel-Gruber syndrome in human. This study revealed a novel role of Wdpcp in regulating coronary artery development in mouse, demonstrating a new pathogenic phenotype associated with mutations of this gene in human. Results of this study may help us to understand the etiology of coronary artery disease.
