Progression of left ventricular hypertrophy in maintenance hemodialysis patients and analysis of risk factors
10.3969/j.issn.1674-8115.2018.05.004
- Author:
Xiao-Mei CHEN
1
Author Information
1. Nephrology Division, The First Hospital Affiliated to Wannan Medical College
- Publication Type:Journal Article
- Keywords:
Cholesterol;
Left ventricular hypertrophy;
Low-density lipoprotein;
Maintenance hemodialysis
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2018;38(5):505-509
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the progression of left ventricular hypertrophy (LVH) in maintenance hemodialysis (MHD) patients, and to analyse risk factors of the progression of LVH. Methods: Stable MHD patients of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine were enrolled in July 2012. These patients were followed for 1 year. Clinical characteristics and laboratory indices were collected at baseline and 1-year followup. Left ventricular mass (LVM) was evaluated by ultrasonic cardiogram. Left ventricular mass index (LVMI) increased more than 5% was defined as LVH progression. Results: Totally 71 MHD patients were enrolled in this study. 44 patients were males, with median age 55.9 years old, median dialysis vintage 152.1 months. 22 (30.99%) patients had LVH at enrollment. A significant higher percentage of MHD patients used calcium-channel binder (CCB) and angiotensin-converting-enzyme inhibitor (ACEI) in LVH group, while a significant higher NT-proBNP level was also showed in LVH group. 31 patients had LVH progression while 40 patients didn't after 1 year. Patients in progression group had significant higher levels of total cholesterol and lowdensity lipoprotein cholesterol (LDL-C). In univariable and multivariable Logistic regression, total cholesterol and LDL-C were independent risk factors of LVH progression (OR=2.515, 95% CI 1.219-5.910, P=0.013; OR=1.950, 95% CI 1.127-3.375, P=0.017). Conclusion: LVH is one of the common cardiovascular complications in MHD patients. The proportion of use of antihypertensive drugs is higher in the patients with LVH. Higher LDL-C and total cholesterol levels are risk factors for the progression of LVH.
