Analysis of liver function, serum lipid and blood routine in patients with differentiated thyroid cancer before radioactive iodine treatment
10.3969/j.issn.1674-8115.2018.06.008
- Author:
Fei XU
1
Author Information
1. Department of Nuclear Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine
- Publication Type:Journal Article
- Keywords:
Differentiated thyroid cancer;
Hypothyroidism;
Iodine radioisotopes;
Liver dysfunction
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2018;38(6):632-636
- CountryChina
- Language:Chinese
-
Abstract:
Objective • To investigate the effect of temporary hypothyroidism state to liver function, serum lipid and blood routine in patients with differentiated thyroid cancer (DTC) prepared for radioactive iodine treatment. Methods • A total of 182 patients with DTC undergoing radical operation of thyroid cancer and radioactive iodine treatment were collected. All these patients were divided into 3 groups by age: 26 in young group (<30 years), 112 in middle-aged group (30-54 years) and 44 in elderly group (≥ 55 years). Indicators of liver function, blood lipids and blood routine were compared before and after operation, among groups as well. Results • Patients under hypothyroidism state had significantly elevations in ALT, AST, LDH and serum bile acid, but a notable decrease of serum bilirubin (all P<0.05). Meanwhile they had remarkable elevations in triglyceride, cholesterol, LDL and HDL (all P<0.05). In the young group before thyroid hypothyroidism treatment, the elevation of ALT, AST, LDH and serum bile acid were more significant than those of the middle-aged and elderly patients (all P<0.05). Conclusion • The temporary hypothyroidism state of differentiated thyroid cancer patients could elevate liver enzymes as well as dyslipidemia.
