Roles of TRIM28 in tumorigenesis and embryogenesis
10.3969/j.issn.1674-8115.2018.07.023
- Author:
Ye LIU
1
Author Information
1. Institute of Embryo-Fetal Original Adult Disease, The International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine
- Publication Type:Journal Article
- Keywords:
Cancer;
Co-activator;
Co-repressor;
Epigenetics;
Methylation;
Transcriptional regulation
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2018;38(7):835-840
- CountryChina
- Language:Chinese
-
Abstract:
TRIM28, known as a kind of macro-molecules, consists of multiple domains and belongs to one of human tripartite motif-containing proteins families. This superfamily contains more than 60 proteins in total and is characterized by four conservative domains, also referred to the RBCC domain, which is a RING (really interesting new gene) finger, two B-boxes (type 1 and type 2) and a leucine zipper coiled-coil region. TRIM28 plays its pivotal roles in transcriptional co-activation or co-repression by interacting directly with transcription factors, within which is a Kruppel-associated box domain (KRAB domain). Moreover, it is critical during the development of embryos, the differentiation of cells and the regulation of cancers.
