Progress in 5-HT2C receptor as a therapeutic target for treatment of schizophrenia
10.3969/j.issn.1674-8115.2018.07.016
- Author:
Ye-Wei WANG
1
Author Information
1. Biochemical Laboratory, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine
- Publication Type:Journal Article
- Keywords:
Antipsychotic induced weight gain;
Gene polymorphism;
Schizophrenia;
Serotonin 2C receptor (5-HT2C receptor);
Vabicaserin
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2018;38(7):801-804
- CountryChina
- Language:Chinese
-
Abstract:
With an increasing number of reports on side effects including antipsychotic induced weight gain and cardiovascular risks, interest of the researchers has been transferred to a new target for the treatment of schizophrenia-serotonin 2C receptor (5-HT2C receptor). On one hand, activation on 5-HT2C receptors can lead to decrease of dopamine in the nigrostriatum, which presents its potential antipsychotic effect; on the other hand, the secondgeneration of antipsychotics’ antagonism on the 5-HT2C receptors is an important factor of patients' weight gain. Conversely, agonism on the 5-HT2C receptors may result in weight loss efficacy. This paper introduced the potential therapeutical effect of 5-HT2C receptor on schizophrenia and the relation between the receptor and correlated weight gain.
