Ubiquitin-like modification (SUMOylation) and genomic stability
10.3969/j.issn.1674-8115.2018.07.001
- Author:
Jin-Ke CHENG
1
Author Information
1. Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University College of Basic Medical Sciences; Shanghai Key Laboratory for Tumor Microenvironment and Inflammation
- Publication Type:Journal Article
- Keywords:
Phosphorylation;
SENP3;
SUMOylation
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2018;38(7):719-721
- CountryChina
- Language:Chinese
-
Abstract:
The mechanism of protein post-translational modifications in regulation of cell mitosis and genomic stability is always a hot issue in biological researches. The present review introduced the functional activity of de-SUMOylase SENP3 in sister chromatin dissociation at mitosis, and demonstrated a new molecular mechanism of cross-talk regulation between protein SUMOylation and phosphorylation in maintaining genomic stability.
