Research progress of role of Pi3k/Akt pathway in mechanism of atypical antipsychotic drugs
10.3969/j.issn.1674-8115.2018.08.015
- Author:
Yan CHEN
1
Author Information
1. Department of Biochemistry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine
- Publication Type:Journal Article
- Keywords:
Adverse reaction;
Atypical antipsychotic drugs (AAPs);
Pi3k/Akt pathway;
Schizophrenia
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2018;38(8):948-953
- CountryChina
- Language:Chinese
-
Abstract:
The alterations of Pi3k/Akt pathway may be critical in the pathogenesis of schizophrenia. Furthermore, atypical antipsychotic drugs can modify Pi3k/Akt pathway, which have been received wide attention. This review mainly focused on four aspects, i.e. metabolic syndrome, changes in immune function, cognitive impairment and neuroprotective effect, and summarized the research progress of role of Pi3k/Akt pathway in the mechanism of atypical antipsychotic drugs.
