Efficacy of Xu-Huang mixtures for the treatment of diabetic lower extremity atherosclerotic occlusive disease
10.3969/j.issn.1674-8115.2018.11.011
- Author:
Jie WANG
1
Author Information
1. Department of Traditional Chinese Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Publication Type:Journal Article
- Keywords:
Clinical effect;
Diabetes;
Lower extremity atherosclerotic occlusive disease (LEAOD);
Xu-Huang mixtures
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2018;38(11):1333-1336
- CountryChina
- Language:Chinese
-
Abstract:
Objective • To observe the clinical efficacy of Xu-Huang mixtures for the treatment of diabetic lower extremity atherosclerotic occlusive disease (LEAOD). Methods • 68 patients with diabetic LEAOD were divided into control group (n=33) and experimental group (n=35) by random number table method. The control group received the oral administration of atorvastatin calcium tablets and beraprost sodium tablets, the experimental group received the same oral administration of the control group plus Xu-Huang mixtures. Two groups were treated for 12 weeks. The intima-media thickness (IMT) of lower extremity artery (including anterior tibial artery, posterior tibial artery and dorsalis pedis artery), blood viscosity, fibrinogen, plasma D-dimer, total cholesterol (TC), low density lipoprotein-cholesterol (LDL-Ch), high density lipoprotein-cholesterol (HDL-Ch) in both groups were recorded at the beginning and end of the treatment. The blood and urine routine examinations and the hepatic and renal function tests were performed every 2 weeks. After treatment, the curative effect of each group was evaluated through measuring the intermittent limp distance. Results • After treatment, the improvement of anterior tibial artery IMT, posterior tibial artery IMT, dorsalis pedis artery IMT, blood viscosity, fibrinogen, plasma D-dimer, TC, LDL-Ch and HDL-Ch in the experimental group were significant superior to that in the control group (all P<0.05). There were no significant abnormalities in the blood and urine routine examinations and the hepatic and renal function tests between two groups. The total effective rate in the experimental group was 91.43%, which was significantly higher than that in the control group (75.76%) (P=0.014). Conclusion • Xu-Huang mixtures has significant efficacy for the treatment of diabetic LEAOD.
