Immunomodulatory effect of myeloid-derived suppressor cell and its impact on tumor therapy
10.3969/j.issn.1674-8115.2019.10.018
- Author:
Xiao LI
1
Author Information
1. Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, Department of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Publication Type:Journal Article
- Keywords:
Immunosuppression;
Myeloid-derived suppressor cell (MDSC);
Tumor therapy
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2019;39(10):1204-1208
- CountryChina
- Language:Chinese
-
Abstract:
Myeloid-derived suppressor cells (MDSCs) are a group of cells with potent immune suppressive activity which have emerged as an important contributor to tumor progression and genesis. More and more clinical researches have found that accumulation of MDSCs in peripheral blood and tumor tissues could predict dismal outcome for patients with malignancies, which was a potential prognostic tumor marker. In addition, immunosuppression induced by MDSCs could reduce the efficacy of anti-tumor therapies. Therefore, better understanding the mechanism of MDSCs’ immune suppression in tumor microenvironment can provide reference for exploring new immunotherapies.
