Association of serum olanzapine concentration and cytochrome P450 1A2 gene polymorphisms: a meta-analysis
10.3969/j.issn.1674-8115.2019.10.011
- Author:
Ye-Wei WANG
1
Author Information
1. Biochemical Laboratory, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine
- Publication Type:Journal Article
- Keywords:
Cytochrome P450 1A2;
Meta-analysis;
Olanzapine;
Polymorphisms;
Serum drug concentrations
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2019;39(10):1167-1171
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate association of cytochrome P450 1A2 (CYP1A2) gene polymorphisms and serum olanzapine concentration. Methods:Key words including “cytochrome P450 CYP1A2”, “genetic polymorphism”, “antipsychotic”, “olanzapine”, “schizophrenia”, and “serum concentration” were used to search in databases, including SinoMed, Wanfang, Weipu, CNKI, PubMed, Embase and Cochrane Library. The search period was limited from the establishment of the database to February 27th, 2018. STATA/SE 12.0 package was applied to conduct statistical analyses. Results: Four studies with a total of 330 schizophrenic patients were included. In the recessive model of CYP1A2 gene -163C>A SNP, patients with A/A genotype had significantly lower olanzapine concentration/dosage ratio (C/D) than patients with C/C or C/A genotype. Conclusion: A/A homozygote of CYP1A2 gene -163C>A SNP is significantly associated with the decreased olanzapine serum concentration.
