Vitamin D in prostate cancer
- Author:
Donald TRUMP
1
Author Information
- Publication Type:Journal Article
- Keywords: Androgens; CYP24A1; inflammation; prostate cancer; vitamin D analogs
- From: Asian Journal of Andrology 2018;20(3):244-252
- CountryChina
- Language:Chinese
- Abstract: Signaling through the vitamin D receptor has been shown to be biologically active and important in a number of preclinical studies in prostate and other cancers. Epidemiologic data also indicate that vitamin D signaling may be important in the cause and prognosis of prostate and other cancers. These data indicate that perturbation of vitamin D signaling may be a target for the prevention and treatment of prostate cancer. Large studies of vitamin D supplementation will be required to determine whether these observations can be translated into prevention strategies. This paper reviews the available data in the use of vitamin D compounds in the treatment of prostate cancer. Clinical data are limited which support the use of vitamin D compounds in the management of men with prostate cancer. However, clinical trials guided by existing preclinical data are limited.
