Establishment of a modified rat laryngeal transplantation model
- Author:
Hao LI
1
Author Information
1. State Key Laboratory of Oncology in Southern China
- Publication Type:Journal Article
- From:
Academic Journal of Second Military Medical University
2006;27(3):322-324
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To develop a modified rat laryngeal transplantation model to improve the survival rate of recipients. Methods: Eighty Class II isogeneic F344 rats, weighing 250-350 g, were randomly divided into 2 groups(n = 40). The control group adopted the Strome model. The allograft used for the experimental group preserved ascending pharyngeal artery, which formed a complex allograft together with tongue base, larynx and pharyngolarynx. End-to-end anastomosis was performed between both allograft common carotid arteries and anterior neck veins. The patency rate and survival rate of the allograft of the 2 groups were compared. Results: The artery, vein patency rate and survival rate were 30%, 15% and 30% in control group, and 75%, 65%, and 80% in experimental group, respectively (P<0.05). Conclusion: The modified rat laryngeal transplantation model improves survival rate of allograft and vessels patency rate, compared with those of Strome model.
