Anti-aging effects of ginsenosides, tanshinone and chuanxionyzine on mice skin: A comparison study
- Author:
Hong-Li WANG
1
Author Information
1. Department of Clinical Medicine
- Publication Type:Journal Article
- From:
Academic Journal of Second Military Medical University
2006;27(5):525-527
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To compare the anti-aging effects of ginsenosides, tanshinone and chuanxionyzine on the skin of D-galactose-induced mice aging model. Methods: One hundred female mice were randomly divided into 5 groups (n =20). Mice in normal control group received subcutaneous injection of normal saline and mice in other 4 groups received cervicodorsal injection of D-galactose (1 000 mg · kg-1 · d-1) for 42 d to establish subacute aging model. The experimental groups included aging model group (without further treatment), tanshinone-treated (1 500 mg · kg-1 · d-1) group, chuanxionyzine-treated (150 mg · kg-1 · d-1) group, and ginsenosides-treated (100 mg · kg-1 · d-1) group. Forty-two days later, the dorsal skin samples were collected to determine SOD, CAT activities and MDA, hydroxyproline contents. Results: In tanshinone- and ginsenosides-treated groups, SOD activities increased from (131.2±21.5) U/ml to (203.1±11.2) U/ml and (196.8±27.5) U/ml, respectively; the contents of hydroxyprolin increased from (0.57±0.13) mg/g to (0.71±0.11) mg/g and (0.76±0.12) mg/g, respectively; and the contents of MDA decreased from (9.39±1.5) nmol/g to (6.4±1.3) nmol/g and (7.16±2.3) nmol/g, respectively (all P<0.05). However, there was no significant difference between the parameters of tanshinone- and ginsenosides-treated groups. Compared with aging control group, there was no obvious changes in the above parameters in chuanxionyzine-treated group. Conclusion: Both ginsenosid es [100 mg/(kg · d)] and tanshinone [1 500 mg/(kg · d)] have noticeable anti-skin aging effects via i. g. administration through improving the activities of antioxidant enzyme and dermal fibroblasts. Chuanxionyzine [150 mg/(kg · d)] shows no anti-skin aging effects in mouse aging models.
