Plasma level of soluble tumor necrosis factor-related apoptosis-inducing ligand in patients with primary biliary cirrhosis: Expression and clinical significance
- Author:
Yan LIANG
1
Author Information
1. Department of Laboratory Diagnostics
- Publication Type:Journal Article
- Keywords:
Biliary;
Hepatitis;
Liver cirrhosis;
Tumor necrosis factors
- From:
Academic Journal of Second Military Medical University
2010;28(2):151-153
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To determine the plasma level of soluble tumor necrosis factor-related apoptosis-inducing ligand (sTRAIL) in patients with primary biliary cirrhosis (PB0 and to explore its clinical significance. Methods: The plasma levels of sTRAIL were examined in 30 patients with PBC, 25 patients with chronic hepatitis and cirrhosis, and 30 healthy donors with ELISA. Meanwhile, the concentrations of plasma gamma7glutamyltransferase (GGT) and alkaline phosphatase (ALP) were examined and their correlation with sTRAIL was analyzed. Results: The plasma level of sTRAIL in PBC patients was (1 543.9 ± 344.2) pg/ml, which was significantly higher than that of healthy donors ([1 098.5±264.7] pg/ml, P0.05). Conclusion: Plasma sTRAIL level is elevated in PBC patients and is correlated with GGT and ALP concentrations, indicating that sTRAIL may contribute to the impair of the intrahepatic bile ducts and is associated with the mobility of PBC.
