Influence of thyroxine treatment on serum lipid levels in patients with subclinical hypothyroidism: A meta-analysis
10.3724/SP.J.1008.2008.00519
- Author:
Li PENG
1
Author Information
1. Department of Endocrinology
- Publication Type:Journal Article
- Keywords:
Hypothyroidism;
Meta-analysis;
Serum lipid;
Thyroxine
- From:
Academic Journal of Second Military Medical University
2010;28(5):519-523
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To examine whether the thyroxine treatment can affect the serum lipid levels in patients with subclinical hypothyroidism by Meta analysis. Methods: Pubmed and China National Knowledge Infrastructure (CNKI) were searched for randomized controlled trials reporting the effectiveness of thyroxine treatment on serum lipid levels in subclinical hypothyroidism patients from January 1980 to September 2006; hand-search was also performed. The included trails were analyzed by RevMan4. 2 software. Results: Six studies were finally included and five of them found thyroxine to be significantly more effective than placebo in improving the serum lipid disorders; one of them found thyroxine had no obvious effect. The pooled effect sizes(95%CI) of total cholesterol(TC),triglyceride(TG), low density lipoprotein cholesterol(LDL-C), high density lipoprotein cholesterol(HDL-C), apoprotein A(ApoA), apoprotein B(ApoB) and lipoprotein a(Lp(a)) were -0.39(-0.71, -0.07), -0.02 (-0.07, 0.04), -0.02(-0.06, 0.03), -0.22(-0.31,-0.12), -0.08(-0.11,-0.06), -0.05(-0.08, -0.02), and -0.38 (-2.41, 1.64), respectively. The analysis results showed that thyroxine treatment was significantly effective on serum levels of TC, LDL-C, ApoA, and ApoB, but not on TG, HDL-C, or Lp(a). Conclusion: This Meta-analysis demonstrates that thyroxine treatment can improve thyroid function and lipid metabolism in patients with subclinical hypothyroidism, reducing the prevalence of artherosclerosis and coronary heart disease.
