Relationship between fatty acid synthase and human epidermal growth factor receptor-2 in tumor cells
- Author:
Yu ZHANG
1
Author Information
1. Molecular Oncology Laboratory
- Publication Type:Journal Article
- Keywords:
Fatty acid synthase;
Gene expression;
Neoplasms;
Receptor, epidermal growth factor;
Signal transduction
- From:
Academic Journal of Second Military Medical University
2010;28(11):1255-1258
- CountryChina
- Language:Chinese
-
Abstract:
Tumor cells have different physiological and biochemical features as compared to normal cells; abnormal expressi of certain genes is also found in tumor cells. Over-expression of genes provide targets for targeted-administration of drugs, which can avoid damage to normal cells during treatment of tumors. Fatty acid synthase (FAS) and human epidermal growth factor receptor-2 (HER2) are both over-expressed in some tumor cells. Herceptin, an HER2-targete4 agent, has been used to treat HER2-positive breast cancer patients worldwide and has obtained satisfactory outcome. Cerulomycin, an agent-targeting FAS, is now in FDA clinical trial. Recent researches have shown that FAS and HER2 are simultaneously over-expressed in some tumors, such as breast cancer cells and ovarian cancer cells; and there is a connection between their signal pathways and a synergistic effect between them. This paper reviews the relationship between FAS and HER2 in tumor cells.
