Tissue Engineering with rhBMP-2: Bone Reconstruction in Implant Dentistry.
10.5051/jkape.1999.29.3.447
- Author:
Ulf ME WIKESJO
1
;
Oliver HANISCH
;
Michael J DANESH-MEYER
;
Kyoo Sung CHO
;
Chong Kwan KIM
Author Information
1. Temple University School of Dentistry, Department of Periodontology Director, Postgraduate Specialty Program in Periodontology Director, Laboratory for Applied Periodontal and Craniofacial Regeneration Diplomate, American Board of Periodontology, USA.
- Publication Type:Review
- Keywords:
Tissue Engineering;
rhBMP-2;
Bone Reconstruction;
Implant Dentistry;
absorbable collagen sponge;
carrier
- MeSH:
Biocompatible Materials;
Ceramics;
Collagen;
Dental Implants;
Dentistry*;
Osseointegration;
Osteogenesis;
Polymers;
Porifera;
Skeleton;
Tissue Engineering*
- From:The Journal of the Korean Academy of Periodontology
1999;29(3):447-468
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The preclinical and clinical studies reviewed herein show that rhBMP-2 induces normal physiologic bone in relevant defects in the craniofacial skeleton. The newly formed bone assumes characteristics of the adjacent resident bone, and allows placement and osseointegration of dental implants. Clearly, the bone inducing capacity of rhBMP-2 is carrier and site dependent. rhBMP-2 in an absorbable collagen sponge carrier induces relevant bone formation in space providing defects. Space providing carries extends this possibility to nonspace providing sites. Notably, some ceramic and polymeric biomaterials may substantially interfere with rhBMP-2 induced osteogenesis.
