Leptin regulates expression of Agouti-related protein in hypothalamus: recent progress
10.3724/sp.j.1008.2009.00569
- Author:
Bin WANG
1
Author Information
1. Department of Pathophysiology, College of Basic Medical Sciences, Second Military Medical University
- Publication Type:Journal Article
- Keywords:
Agouti-related protein;
Energy metabolism;
Leptin s FoxOl;
Stat3
- From:
Academic Journal of Second Military Medical University
2010;30(5):569-571
- CountryChina
- Language:Chinese
-
Abstract:
Hypotha is the center of energy homeostasis in the organism. The central step of its endocrinology regulation network is that it can receive the leptin signal provided by peripheral adipose tissues,and subsequently modulate the expression of Agouti-related protein (AgRP) and proopiomelanocortin (POMC) , maintaining energy homeostasis by regulating energy intake and consumption. Transcription factors FoxOl and STAT3 (signal transducer and activator of transcription 3) are key molecules in leptin-mediated transcriptional regulation of AgRP; they directly participate in the regulation of energy homeostasis. FoxOl can enhance AgRP expression and activated STAT3 can inhibit AgRP expression. Leptin can modulate AgRP and energy homeostasis through inhibiting FoxOl activity and activating STAT3. The article reviews the regulatory mechanism of leptin upon AgRP.
