Gender difference in activation of platelets in septic rats
10.3724/SP.J.1008.2009.00249
- Author:
Jin-Yu HU
1
Author Information
1. Deprtment of Anaesthesiology
- Publication Type:Journal Article
- Keywords:
Blood platelets;
Estrogens;
Gender factors;
Sepsis
- From:
Academic Journal of Second Military Medical University
2010;30(3):249-251
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the influence of gender difference on the activation of platelets in septic rats. Methods: Totally 20 female and 20 male SD rats were randomly divided into four groups: male sham-operated group, female sham-operated group, female septic group, and male septic group, with each group containing 10 rats. Sepsis model in the last two groups was produced by cecal ligation and puncture (CLP); rats in the sham-operated group received no CLP. The rats were sacrificed 24 hours after surgery; the blood samples were collected for blood routine test; and the serum β-TG levels were detected by ELISA assay. Serum estrogen (E2) levels were detected by radioimmunoassay. Results: The blood platelet counts were decreased in both septic rats of both genders; the count in female rats was significantly higher than in the male rats (P< 0.01). The serum β-TG levels were increased in septic rats of both genders; the level in the female rats was significantly lower than that in the male rats (P<0.01). The blood platelets count in female or male septic rats was significantly positive correlation with the level of serum estrogen and the β-TG expression in female or male septic rats was significantly negative correlation with the level of serum estrogen(P<0.05). Conclusion: There is a gender difference in the activation of platelets in septic rats, and the endogenous estrogen may have protective effect on the platelets of female septic rats.
