Voltage-gated potassium channels and trigeminal neuralgia
10.3724/SP.J.1008.2009.00432
- Author:
Na LI
1
Author Information
1. Department of Anaesthiology
- Publication Type:Journal Article
- Keywords:
Dorgalroot ganglia;
Receptors;
Trigeminal ganglion;
Trigeminal neuralgia;
Voltage-gated potassium channels
- From:
Academic Journal of Second Military Medical University
2010;30(4):432-436
- CountryChina
- Language:Chinese
-
Abstract:
Voltage-gated potassium channels regulate cell membrane potential and excitability in neurons. Trigeminal ganglion as a primary sensory neuron plays an important role in the pain transduction and transmission of trigeminal neuralgia. Trigeminal ganglion neurons express many subtypes of voltage-gated potassium channels and they can evoke different type of K+ current when activated. The alteration of voltage-gated potassium channels and their interaction with neurotransmitters, inflammatory cytokines and receptors play important roles in the development of trigeminal neuralgia.
