Studies on chemical constituents of Anthogorgia sp

Author: Yuan-Yuan XU ¹
Author Information

1. Research Center for Marine Drugs
Publication Type:Journal Article
Keywords: Anthogorgia sp.; Ceramides; Steroids
From: Academic Journal of Second Military Medical University 2010;31(4):421-424
CountryChina
Language:Chinese
Abstract: Objective: To study the chemical constituents of Anthogorgia sp. collected from Beihai area of Guangxi Zhuang Autonomous Region, China. Methods The Et 2O extract of Anthogorgia sp. was subjected to repeated silica gel (eluted with Pe: Ac=99:1, 49:1, 39:1, 34:1, 29:1, 24:1, 19:1, 14:1, 11:1, 9:1, 8:1, 7:1, 6:1, 5:1, 4:1, 3:1, 2:1, 1:1, 100%Ac; CHCl3:MeOH=24:1, 19:1, 14:1, 9:1, 7:1, 5:1, 3:1, 1:1, 1:4, 1:9, 1:39, 100% MeOH) and Sephadex LH-20 column chromatography (n-hexane:CHCl3:MeOH=2:1:1) for isolation and purification. The structures of the resultant compounds were elucidated using spectroscopic analysis (1 H NMR, 13C NMR and MS). Results: Six steroids and one ceramide were isolated and identified as: Ergost-5, 24(28)-dien-3β-ol(1),(22E,24R)-ergost-7,22-dien-3β,5α, 6β-triol(2),(22E,24S)-ergost-5,22-dien-3β-ol(3), cholesta-5-en- 3β,7β,19α-triol(4),(22E)-cholesta-5,22-dien-3β-ol(5), cholesterol(6), and N-palmitoyloctadecasphinga-4(E)-ene(7). Conclusion: All the six compounds are isolated from Anthogorgia sp. for the first time.