Lipid raft involved in drug resistance: Relationship between multidrug resistance ATP-binding cassette transporters and lipid raft
10.3724/SP.J.1008.2011.00213
- Author:
Lin WANG
1
Author Information
1. Department of Pharmacology
- Publication Type:Journal Article
- Keywords:
ATP-binding cassette transporters;
Candida albicans;
Lipid raft;
Multidrug resistance
- From:
Academic Journal of Second Military Medical University
2011;32(2):213-215
- CountryChina
- Language:Chinese
-
Abstract:
Lipid rafts have been implicated in many cellular functions, including protein and lipid transport and signal transduction. Recently ATP-binding cassette (ABC) transporters, which are associated with multidrug resistance, have been found in lipid rafts; therefore they might be related to drug resistance. Here we introduce the relationship between the localization and functions of three multi-drug related ABC transporters, including two relevant to multidrug resistance in tumor cells(Pgp/ABCB1 and MRP1/ABCC1) and one relevant to multidrug resistance in Candida albicans (Cdrlp). We also discuss the influence of sphingolipids and cholesterol, two major components of lipid rafts, on the localization and function of the above three ABC transporters.
