Role of K-ras gene mutations in carcinogenesis, diagnosis and treatment of patients with lung adenocarcinoma
10. 3724/SP. J. 1008. 2011. 00545
- Author:
Bin WANG
1
Author Information
1. Department of Respiratory Medicine
- Publication Type:Journal Article
- Keywords:
Adenocarcinoma;
Diagnosis;
K-ras gene;
Lung neoplasms;
Neoplasm drug resistance;
Prognosis;
Smoking;
Therapy
- From:
Academic Journal of Second Military Medical University
2011;32(5):545-549
- CountryChina
- Language:Chinese
-
Abstract:
K-ras gene mutalion iscommonly seen in lung adenocarcinoma. Cigarette smoking is thought to be an important reason for K-ras gene mutation. Studies have repotted that K-ras mutations can influence the subtyping and prognosis of lung adenocarcinoma. Recently, the techniques to detect K-ras mutation have been continuously improved, greatly promoting the detection sensitivity of K-ras mutations, even in tissues with small amount of tumor component. Emerging data showed that K-ras mutation can induce primary resistance of lung adenocarcinoma to tyrosine kinase inhibitors (TKIs) and decrease the efficacy of chemotherapy. Therefore, K-ras mutation has attracted considerable attention as a target for diagnosis and anticancer therapy. In this review, we summarize recent studies on K-ras mutations in lung adenocarcinoma, and discuss the development, diagnosis, and treatment of lung adenocarcinoma.
