Pre-radiotherapy immunological state in patients with esophageal carcinoma and prognosis: A correlation analysis
10.3724/Sp.J.1008.2012.01223
- Author:
Jian HE
1
Author Information
1. Department of Oncology, Changzheng Hospital, Second Military Medical University
- Publication Type:Journal Article
- Keywords:
Esophageal neoplasms;
Natural killer cells;
Prognosis;
Radiotherapy;
T-lymphocyte subsets
- From:
Academic Journal of Second Military Medical University
2012;33(11):1223-1226
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the pre-radiotherapy immunological state in patients with esophageal carcinoma, and to explore its association with the clinical pathological characters and prognosis. Methods: Totally 91 patients with pathologically confirmed esophageal cancer received radiotherapy. The proportions of T-lymphocyte subsets and natural killer (NK) cells in the peripheral blood were detected by the flow cytometry before radiotherapy; healthy population was taken as control. The correlation of immunological stress state and clinical pathological parameters were further evaluated in the patients. Univariate analysis (Kaplan-Meier) and multivariable analysis (Cox proportional hazards regression analysis) were used for survival analysis. Results: The proportions of CD3+CD4+ (Th) T cells, CD8+ CD28+ T cells and NK cells in pre-radiotherapy esophageal carcinoma patients were significantly lower than those in the healthy population (P<0. 05). We also found that the proportion of CD3+ CD8+ (Ts) T-lymphocytes was positively correlated with lymph node metastasis (P<0. 05) and the proportion of NK cells was positively correlated with TNM stage (P<0. 05). Univariate analysis showed that the patients with high proportions of The or CD8+CD28+ T cells had a better survival (P<0. 05). The multivariate analysis revealed that the proportion of The cells before radiotherapy was an independent prognostic factor for patients with esophageal carcinoma. Conclusion: The pre-radiotherapy proportion of The cells in the peripheral blood is an independent prognostic factor for patients with esophageal carcinoma.
