Biological characteristics and regulatory mechanisms of hepatic progenitor cells: Recent progress
10.3742/sp.j.1008.2012.01129
- Author:
Ming-da WANG
1
Author Information
1. Eastern Hepatobiliary Surgery Hospital, Second Military Medical University
- Publication Type:Journal Article
- Keywords:
Biomarker;
Cell differentiation;
Hepaticprogenitor cells;
Hepatocellular carcinoma;
Signaling pathway
- From:
Academic Journal of Second Military Medical University
2012;33(10):1129-1134
- CountryChina
- Language:Chinese
-
Abstract:
Hepatic progenitorcells (HPCs) are adult stem cells with self-renewing, high proliferation and multidirectional differentiation abilities. HPCs are closely associated with liver regeneration and the development of hepatocellular carcinoma (HCC). This article reviews recent research progress in biological characteristics, source, location ofHPCs and the roles of various HPCs signalings in the proliferation, differentiation and development of HCC.
