Reduction of plasma decorin following acute ischemic stroke and its clinical significance
10.3724/SP.J.1008.2012.00654
- Author:
Yuan-zhi XU
1
Author Information
1. Department of Neurosurgery, Center of Clinical Neuroscience, Changhai Hospital, Second Military Medical University
- Publication Type:Journal Article
- Keywords:
Decorin;
Extracellular matrix;
Matrix metalloproteinases;
Stroke
- From:
Academic Journal of Second Military Medical University
2012;33(6):654-658
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of plasma decorin in patients with acute ischemic stroke and its clinical significance. Methods The plasma levels of decorin were assessed in 102 patients with acute ischemic stroke (< 7 days) and 120 control subjects using ELISA. Then we evaluated the relationship between decorin level and the TOAST subtypes of stroke, so as to analyze the role of decorin level in diagnosis and treatment of acute ischemic stroke. Results Compared with the control group, the decorin level was significantly decreased in acute ischemic stroke group (P<0. 001), and that in the large-artery atherosclerosis group was lower than those in other groups of the same level. According to the receiver operating characteristic curve, decorin level was a diagnostie marker for acute ischemic stroke (P<0. 001). Decorin levels
