Serum HMGB-1 level and its correlation with p53 and clinical pathology in patients with liver cancer
10.3724/SP.J.1008.2012.00103
- Author:
Ke-ji CHEN
1
Author Information
1. Department of Biliary Surgery II, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University
- Publication Type:Journal Article
- Keywords:
Clinical pathology;
Enzyme-linked immunosorbent assay;
Liver neoplasms HMGB-1 protein;
Tumor suppressor protein p53
- From:
Academic Journal of Second Military Medical University
2012;33(1):103-105
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the serum level of high mobility group box-1(HMGB-1) in patients with liver cancer and its correlation with p53 and clinical pathological features of liver cancer. Methods Serum levels of HMGB-1 and p53 were determined by ELISA m 20 patients with hepatocellular cacinoma, 20 with cholangiocellular carcinoma and 20 healthy V0lunteers. Resists Serum HMGB-1 levels in hepatocellular cacinoma patients ([83. 8 ± 17. 4] ng/ml) and cholangiocellular careinoma patients ([95. 9 ± 21. 4] ng/ml) were significantly higher than that in the healthy Volunteers ([8. 4 ± 2. 6] ng/ml, P<0. 05). Serum p53 levels in hepatocellular cardnoma patients ([251. 0 ± 45. 6] pg/ml) and cholarigtocellidar carein0ma patients ([267. 8 ± 47. 4] pg/ml) were also significantly higher than that in the healthy Volunteers ([160. 0 ± 28. 4] pg/ml, P<0. 05). Serum HMGB-1 level was p0eisively correlated with the serum p53 level in the hepatocellular careln0ma patients (r=0. 660 3, P<0. 05) and cholargtocellular carelnoma patients (r = 0. 614 2, P<0. 05). Serum HMGB-1 and p53 levels were not correlated with the age, gender, tumor, or member of tumors (P>0. 05), between correlated with the TNM stage, differentation degree and metastaeis status (P<0. 05). Conclusion Serum HMGB-1 level is positively correlated with p53, and both HMGB-1 and P53 influence the pathogenesis of liver cancer.
