Protective effect of DJ-1 against oxidative stress: An advance
10.3724/SP.J.1008.2012.00088
- Author:
Zhi-yong WANG
1
Author Information
1. Department of Dermatology, Xijing Hospital, Fourth Military Medical University
- Publication Type:Journal Article
- Keywords:
Apoptosis;
DJ-1/PARK7 gene;
Oxidative stress
- From:
Academic Journal of Second Military Medical University
2012;33(1):88-91
- CountryChina
- Language:Chinese
-
Abstract:
Oxidative stress is implicated in the pathogenesis and progression of various diseases as well as in the natural aging process. DJ-1/PARK7 gene encodes DJ-1 protein, which participates in malignant transformation, sperm maturation and fertilization, cell proliferation promotion, and anti-oxidative stress. The anti-oxidative stress effect of DJ-1 has been drawing increasing attention in recent years. There have been related in vitro, in vivo and clinical studies. The main mechanisms of its anti-oxidation effects included modifying configuration, playing the role of molecular chaperones, protecting the mitochondrial function, and regulating anti-apoptosis genes and antioxidant-related genes. Further research on DJ-1 may provide a new strategy for the prevention and treatment of oxidative stress-related diseases.
