Expression and significance of YKL-40 and VEGF in condyloma acuminatum tissues
10.3724/SP.J.1008.2013.00639
- Author:
Qiang LIU
1
Author Information
1. Department of Dermatology, Changhai Hospital, Second Military Medical University
- Publication Type:Journal Article
- Keywords:
Apoptosis;
Condylomata acuminata;
Vascular endothelial growth factors;
YKL-40
- From:
Academic Journal of Second Military Medical University
2013;34(6):639-644
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of YKL-40 and vascular endothelial cell growth factor (VEGF) in condyloma acuminatum (CA tissues and the related significance. Methods The expressions of YKL-40 and VEGF were analyzed by immunocytochemical staining with streptavidin-peroxidase (SP) in 33 CA tissues and 10 foreskin tissues of normal person. Results The expression intensities of YKL-40 and VEGF varied largely from positive (#) to strongly positive ($) in CA tissues compared with negative ( - ) and positive ( + ) in normal foreskin tissues. The expressions of YKL-40 and VEGF proteins in CA tissues were significantly different from those in the normal human controls(P0. 05). No correlation was found between the expression of YKL-40 and VEGF proteins in CA tissues (r = 0. 27, P^>0. 05), and their expressions were not correlated with other clinical factors (P>0. 05). Conclusion YKL-40 and VEGF are over-expressed in CA tissues, which may play a part in the occurrence and development of CA.
