Clinical factors of cyclosporine A-induced gingival overgrowth and serum cyclophilin A in renal transplant recipients
10.3724/SP.J.1008.2013.00515
- Author:
Lei JIANG
1
Author Information
1. Department of Stomatology, Changzheng Hospital, Second Military Medical University
- Publication Type:Journal Article
- Keywords:
Cyclophilin A;
Cyclosporine;
Gingival hyperplasia;
Kidney transplantation
- From:
Academic Journal of Second Military Medical University
2013;34(5):515-520
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the clinical factors of renal transplant recipients medicated with cyclosporine A (CsA) and gingival overgrowth (G0), so as to evaluate the association of serum cyclophilin A (CyPA) with CsA-induced G0. Methods Totally 65 renal transplant recipients were enrolled in this study. The degrees of G0 were evaluated using gingival overgrowth index (G0I) and the patients were subsequently grouped into overgrowth (GO+) and nonovergrowth (GO-). The age, gender, medication duration, dosage of immunosuppressive agents, serumconcentrations of CsA and CyPA, creatinine, ureal and gingival assessments were compared between the two groups. The possible correlation between CyPA level and the development and severity of CsA-induced G0 was also identified. Results The number of G0+ subjects (GOI≥30) was 14 (21. 54%) in the present patients. There wereno significant differences in age, gender and medication duration, dosage of immunosuppressive agents, serum concentration of CsA, serum creatinine or ureal level between the two groups. Serum CyPA level in GO+ group was significantly lower than that in GO- group (0. 23 [0. 16-0. 30] ng/mL vs 0. 34 [0.22-0.54] ng/mL, P = 0. 04). Serum CyPA concentration was negatively correlated with G0 degree (r=-0. 264, P = 0.03), and was not correlatedwithdosage or concentration of CsA (r=-0.014, P = 0. 91; r = 0.012, P = 0. 93). In addition, the patients with G0 presented a significantly high plaque index and papilla bleeding index than those without G0 (1. 41±0. 27 vs 1. 15±0. 34, P = 0. 01; 0. 49±0. 30 vs 0. 25±0. 11, P = 0. 01). Conclusion Development of CsA-induced G0 may be due to a co-work of both local and system factors; serum CyPA level might be an risk factor for CsA-induced G0 independent to dosage and serum CsA, Which may help to detect GO in clinic.
