Nitration of α-Synuclein in Parkinson disease: Recent progress
10.3724/SP.J.1008.2015.00423
- Author:
Yan WANG
1
Author Information
1. Department of Pharmaceutical Analysis, School of Pharmacy, Second Military Medical University
- Publication Type:Journal Article
- Keywords:
Nitration;
Parkinson disease;
α-synuclein
- From:
Academic Journal of Second Military Medical University
2014;36(4):423-428
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson disease (PD) is characterized by the degeneration of dopaminergic neurons in the substantial nigra and the formation of intracellular Lewy body. Protein nitration due to oxidative and nitrative stress has been linked to the pathogenesis of PD. Here we described the biophysical and biochemical properties of α-synuclein and nitrated α-synuclein protein and reviewed their biological consequences; finally we discussed their roles in the mechanism and prevention/treatment of PD.
