C3 glomerulopathy: Advances in diagnosis and treatment
10.3724/SP.J.1008.2014.01373
- Author:
Yun-Jia SUN
1
Author Information
1. Student Brigade, Second Military Medical University
- Publication Type:Journal Article
- Keywords:
C3 glomerulonephritis;
C3 glomerulopathy;
Complement C3;
Dense deposit disease
- From:
Academic Journal of Second Military Medical University
2014;35(12):1373-1377
- CountryChina
- Language:Chinese
-
Abstract:
C3 glomerulopathy is a recently defined disease category comprising several rare types of glomerulonephritis (GN), including dense deposit disease (DDD), C3 glomerulonephritis (C3GN), and CFHRS nephropathy. These disorders share a common etiology involving dysregulation of the complement alternative pathway (AP), with genetic defects and/ or autoantibodies seen in a proportion of patients. Currently no consistently effective therapy has been found for C3 glomerulopathy; clinical evaluation of agents targeting specific components of the complement system is undergoing. The appropriate timing and duration of proposed therapies need to be further explored. This review focuses on the clinical and histological features, complement tests and treatments of C3 glomerulopathy.
