Lack of dopamine D2 receptor exacerbates MPTP-induced Parkinson's disease in mice
10.3724/SP.J.1008.2014.01353
- Author:
Yan HUANG
1
Author Information
1. Department of Physiology, School of Medicine, Nantong University
- Publication Type:Journal Article
- Keywords:
Dopamine D2 receptors;
Knockout mice;
MPTP poisorting;
Parkinson disease
- From:
Academic Journal of Second Military Medical University
2014;35(12):1353-1357
- CountryChina
- Language:Chinese
-
Abstract:
Results After MPTP injection, the animals had a significantly longer time in pole testing, a significantly decreased score in swimming test, and a significantly decreased number of TH-positive neurons in the substantia nigra of the midbrain (P < 0. 05 or P<0. 01). Moreover, the behavioral changes and the decrease of TH-positive neuron numbers in D2-/- mice were more significant than those in the WT mice(P< 0. 05 or P<0. 01).
